Pain is caused by inflammation. Reduce or stop inflammation and you've found the secret to cost-effective, safe, and effective pain control supplement. JPR MegaTM is our most potent and effective proprietary Cyclooxygenase (COX) Curcuminoid Complex extract that was discovered in the quest for reducing inflammation and joint pain caused by arthritis. Whether you have muscle aches, joint pain, backaches, leg pain, or aches and pains from overexertion, JPR Mega is there to comfort you. JPR Mega includes dl-phenylalanine (DLPA), an essential amino acid that is crucial in preventing the breakdown of endorphins, the feel-good hormones, in the brain. Some have characterized the endorphins as natural morphine-like substances that drastically increase our tolerance of pain. COX-2 inhibitors are a subclass of nonsteroidal antiinflammatory drugs. NSAIDs work by reducing the production of prostaglandins, chemicals that promote inflammation, pain, and fever. Prostaglandins also protect the lining of the stomach and intestines from the damaging effects of acid. The enzymes that produce prostaglandins are called cyclooxygenase (COX).